This article reports a case of acute pulmonary infarction in a patient with benign symmetric lipomatosis complicated with severe obstructive sleep apnea-hypopnea syndrome (OSAHS) after secondary surgery. The first neck lipoma resection was performed 10 years ago, and the tumor recurred 2 years ago. After the recurrence, the patient underwent a similar modified neck dissection under general anesthesia. On the 3rd day after the operation, she developed chest tightness and shortness of breath. Pulmonary infarction was confirmed by deep vein ultrasound and CT angiography (CTA) of the pulmonary artery, and the pulmonary thrombus disappeared under anticoagulation therapy and close monitoring. During the 3-month follow-up, the patient's neck wound healed well, and the symptoms of snoring and suffocation were significantly relieved