Journal ID : CJOHNS-23-06-2024-11459
[This article belongs to Volume - 55, Issue - 06]

Title : A Study of Histological Grading and Biochemical Functional Analysis of Salivary Components in Patients with Head and Neck Carcinoma Receiving Definitive Chemo-And Radiotherapy

Abstract :

The goal of the current study is to examine salivary component biochemical functional analysis, and histological grading in patients with head and neck cancer undergoing final chemotherapy and radiation treatment. A study enrolled 60 patients with head and neck malignancies who had salivary samples taken at baseline, three months, and six months post-chemo and radiation. Histological data analysis included H&E stained slides, biochemical analysis, diagnostic tests, and a one-sample t-test. The study used a Cobalt 60 machine with a radiation dosage of ≥60 Gy and a graded periodontal probe to quantify clinical practice decline in periodontal reliance. To quantitatively analyze the data and determine the importance of the disparities, we employed the Chi-square test. 10% of the cases (n = 6) had a well-differentiated histology, whereas 90% of the cases (n = 54) had a moderately differentiated histology. Based on the criteria, 35 percent of the cases fell into stage III (n = 33), 36.6% into stage II (n = 22), and 8.4% into stage I (n = 5). Both of the grading systems that are currently in use are in use, albeit having somewhat different definitions. A multivariate study was conducted to ascertain the real clinical significance of grading as such. The study examined saliva concentrations during radiation therapy, revealing high albumin levels at the start, low electrolyte levels, and high calcium and protein levels, with a trend toward baseline values. The study concluded that head and neck cancer components should be considered, as their predictive value is similar to conventional grading systems. Saliva's biochemical properties are altered by radiation and chemotherapy due to damage to the salivary acinar gland. Saliva becomes thick, rare, tenacious, and acidic. Inflammation affects periodontal tissue cells, releasing AST and LDH. Salivary concentrations can be used as diagnostic and prognostic indicators.

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