Journal ID : CJOHNS-27-06-2024-11462
[This article belongs to Volume - 55, Issue - 06]

Title : CORRELATION BETWEEN ANESTHESIA TECHNIQUES AND LONG TERM ONCOLOGICAL OUTCOMES IN PATIENTS WITH ORAL CANCER SURGERY

Abstract :

We have conducted a descriptive study to assess correlation between anesthesia techniques and long term oncological outcomes in patients with oral cancer surgery. The research project examined the computerised clinical records of patients treated at hospital for oral cancer that was ultimately curable. No preliminary medication was given before the administration of anesthesia, and the participants were categorized according to the kind of anesthesia they had undergone. Rocuronium, propofol, midazolam, and fentanyl were used to produce anesthesia. Data was gathered about the patient's demographics, about cancer, and about surgery and post-operative care. SPSS Statistics version 26.0 was used for all analyses, with the chi-squared test for categorical variables and the Student's t-test for continuous data. The majority of tumors in both categories, particularly in the propofol group, were found in the tongue. Each group's variables were evenly distributed using propensity score matching (p>0.05). The propofol and sevoflurane groups did not significantly vary in terms of overall survival or recurrence-free survival. Ten variables that had a p-value of less than 0.05 were added to the multivariate model based on the univariate analysis of overall survival. Following multivariate analysis, there was no discernible difference between the sevoflurane and propofol groups' overall survival rates. Poor overall survival was correlated with older age (p = 0.001), advanced TNM stage (TNM III: p = 0.000 and TNM IV: p = 0.003), and ASA class III. It is determined that among patients undergoing oral cancer surgery, the overall and recurrence-free survival rates were comparable for both sevoflurane volatile anesthesia and propofol-based intravenous anesthesia.

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