Journal ID : CJOHNS-29-05-2024-11452
[This article belongs to Volume - 55, Issue - 06]

Title : CORRELATION BETWEEN HEPATIC STEATOSIS AND VITAMIN D INSUFFICIENCY IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE (NAFLD): A CASE-CONTROL STUDY

Abstract :

The study aims to determine the correlation between hepatic steatosis and vitamin D insufficiency in patients with nonalcoholic fatty liver disease (NAFLD). A case-control study was conducted at the Department of Biochemistry, Ayub Medical College, Abbottabad, Pakistan, from July 2023 to December 2023, and the Ethical Committee of the Institution approved our study. After the initial screening, only 208 were considered for data analysis. Ultimately, 100 chronological and gender-matched controls and 108 NAFLD patients with a diagnosis participated in this investigation. The statistical analysis was performed via SPSS version 23.0. A logistic regression analysis was expanded and included potential components in the univariate analyses to find the independent predictors of NAFLD (<0.05 was used as a statistically significant). In Controls, laboratory values were shown to increase level. Vitamin D serum has a significant value (P-value 0.001), and fasting blood glucose (FBG) showed a significant p-value of 0.004. In contrast, uric acid, aspartate aminotransferase (AST), and Ferritin showed a same p-value of 0.000. There was a significant correlation found between 25(OH)D levels and HDL-C levels (p = 0.004), uric acid levels (p = 0.005), HbA1c levels (p = 0.002), the urinary albumin/creatinine ratio (p = 0.001), FBG rates (0.031), and the erythrocyte sedimentation rate (ESR) (<0.001). It is concluded that serum vitamin D levels were reduced in cases with NAFLD than in controls. Further studies are needed to evaluate more evidence-based studies.

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