Skull base osteoradionecrosis (sbORN) is one of the serious complications after radiotherapy for nasopharyngeal carcinoma, which significantly affects the survival time and quality of life of patients. sbORN and the internal carotid artery (ICA) rupture caused by sbORN are independent risk factors affecting the 5-year overall survival rate of patients. The clinical curative effect of this disease is not good, which is the difficulty in the clinical diagnosis and treatment of nasopharyngeal carcinoma. In addition, the structure of the skull base is complex, including important structures such as ICA and cranial nerves. Once it occurs, the clinical harm will be huge. This article intends to summarize the current status and progress of the treatment of sbORN in nasopharyngeal carcinoma at home and abroad in recent years, aiming to provide clinical reference for the treatment of this disease.