Histological Changes in Liver Followed By Administration of Extract of Fagonia Cretica Linn in CCL4 Induced Hepatotoxic Rats

To investigate histopathological changes of Fagonia Cretica Linn extract in CCL4 induced hepatotoxic rats. In present study twenty-four rats of weight 200 – 250 g were used. They were randomly divided into four groups, group I, II, III, and IV. Group I was served as normal control (only normal saline was given), in group II, III and IV hepatotoxicity were induced by given ip injection of carbon tetrachloride (2ml/kg body weight) group II was served as negative control in which normal saline was given, group III was positive control in which silymarin (2ml/kg ip) was given and group IV was served as test group in which extract of Fagonia cretica (200mg/kg ip) was given.Treated daily with extract of Fagonia cretica (200mg/kg) and silymarin (2ml/kg) showed protective effect on histology of liver in CCL4 induced Hepatotoxic rats. The present study concludes that methanolic extract of Fagonia cretica have protective effect on histology of liver in animal model.