Journal ID : CJOHNS-31-03-2023-11355
[This article belongs to Volume - 58, Issue - 02]

Title : Immunohistochemical Evaluation of Expression Pattern of p53 in Oral Premalignant Lesions and Follow-up of the Patients with These Lesions

Abstract :

Recent studies indicate increasing the oral cancer especially in young women, which mostly originates from a precancerous lesion. This study evaluates 8-year follow up of the patients with oral premalignant lesions and evaluation of p53 expression in these lesions. Out of 94 follow-up cases, 80 samples (11 epithelial hyperplasia,17 epithelial hyperplasia with mild dysplasia,17 epithelial hyperplasia with moderate dysplasia, 9 epithelial hyperplasia with severe dysplasia, 10 lichen planus, 8 lichen planus with mild dysplasia, 8 lichen planus with moderate dysplasia) for p53 staining were included in this research. MTR (malignant transformation rate) was 0%. The prevalence of oral precancerous lesions was somewhat higher in women (52.5%). Tongue (45.76%), buccal mucosa (42.37%), gingiva (6.8%), lip (3.38%), and palate (1.69%) were the most prevalent locations of epithelial dysplasia. When compared to non-dysplastic lesions, dysplastic lesions had higher levels of p53 expression and intensity (epithelial hyperplasia with dysplasia >epithelial hyperplasia (P = 0.014) and lichen planus with dysplasia >lichen planus (P = 0.001). In addition, as the degree of dysplasia increased, p53 expression and intensity also increased. Increased levels of p53 protein expression, intensity, and distribution in the statistical groups examined in the current work demonstrate the significant contribution of p53 to dysplastic alterations and suggest that p53 may be a useful tool for determining the extent of dysplastic changes. This research shown that maybe p53 does not have a significant role in the development of dysplastic lesions into oral squamous cell carcinoma (OSCC).

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