The flipped classroom is an innovative pedagogical strategy in education in general and in nursing and health technology education in particular, thanks to its multiple advantages such as flexibility, autonomy, and the development of reflection skills. The present study aimed to investigate the impact of the flipped classroom on the grades of health students. This is an exploratory quantitative pre- and quasi-experimental study aimed at investigating the impact of the flipped classroom on the grades of health students at the Higher Institute of Nursing Professions and Technical Health in Agadir. 3 experiences were used; 2 pre-experimental studies with paired samples and 1 quasi-experimental study using independent samples. The results of this study showed a significant increase in students' marks after using the flipped classroom in 3 different experiences and the presence of a significant relationship between the marks and the gender of the participants in experience B (p=0.05) and experience C (p=0.000). In contrast, there was no significant relationship between marks and age in the 3 experiences. The synergy between the administration through the implementation of platforms and teacher training, the teachers through the use of the flipped classroom, and the students through their commitment will be highly recommended for the application of the flipped classroom for the success of students and the development of their skills.