Despite progress in obstetric and neonatal care, perinatal morbidity and mortality is a major public health problem for a country's development and remains a global issue, particularly in developing countries. However, it reflects the living conditions and socioeconomic development of a population, the accessibility to health services, the quality, availability and safety of maternal and child health services and resources. The objective of this systematic review was to describe the epidemiology of neonatal morbidity and mortality in Morocco for the period 2010 to 2021 in terms of neonatal, maternal, and obstetric frequency and characteristics. The bibliographic search was carried out on the MEDLINE (PubMed), Scopus and Web of Science databases, Cairn info, IEEE Explore, HINARI, Science Direct, Springer Link and Google Scholar. Observational cross-sectional or cohort studies conducted in Morocco on the prevalence of morbidity and/or mortality in live newborns and/or those who died before 28 days and/or developed conditions during the period 2010 and 2021 were included. The overall effect measure was calculated via the random-effects model. Publication bias was analyzed by funnel plot and Begg test. The meta-analysis software R version 4.1.2 was used for statistical analysis. Of 278 identified articles, 18 articles were included. The pooled prevalence of neonatal morbidity was 6.14% (IC95% [2.63 -13.65]) and the pooled prevalence of neonatal mortality was 0.60% (IC95% [0.18 - 1.97]). Heterogeneity was significantly high between studies with rates of (I²= 100%, p<0.001) and (I²= 90%, p<0.01) respectively. The results of this systematic review should be interpreted as a synthesis of knowledge on neonatal health in Morocco for the last 11 years. It appears essential to conduct large-scale factorial and multicenter studies in order to understand the causes of neonatal morbidity and mortality in Morocco and to contribute to its reduction accordingly.