Propofol and Ciprofol as an Anesthetic Agent: Safety and Efficacy in Gynecological Surgeries

It is unknown if ciprofol is used to sedate outpatients having gynecological procedures. For this reason, we created this non-inferiority study to evaluate the safety and effectiveness of ciprofol as compare to propofol in outpatient gynecology. Bangladeshi and Pakistani hospitals served study as the sites for this multicenter, randomly allocated, parallel-group. The ClinicalTrials.gov registration for the trial strategy was made prospectively and approved by the Biomedical Research Ethics Committee (2022-052, June 25, 2023) and other participating facilities. A sample size of 105 patients was required for the purpose to assess the variation between the two categories. In a 2:1 ratio, we allocated patient to either the propofol group (N=60) or the ciprofol group (N=45). Except for the proportions of the two groups with histories of induced abortion, baseline characteristics were largely equal. In both groups, 100% of the sedation attempts were successful. In terms of additional outcomes, patients receiving ciprofol compared to those getting propofol had a longer time to achieve successful induction (median difference, 95% confidence interval, 1 to 7; p < 0.001). The two groups' anesthesiologists' and surgeons' satisfaction ratings and dissatisfaction rates did not differ significantly. Mean was greater in patients who administered ciprofol throughout the procedure. During the procedure, there were no noticeable differences in HR between the two groups. It is concluded that the administration of anesthesia to adult patients having ambulatory gynecological procedures, ciprofol did not perform any worse than propofol.