Chronic rhinosinusitis (CRS) is a common upper respiratory tract inflammatory disease with a high prevalence and complex pathological mechanisms. CRS intrinsic type is a classification based on its biomarkers and molecular mechanisms, which is the key to understanding the nature of the disease, accurate diagnosis, precise treatment and improving curative effect. This article reviews the new progress of the intrinsic type of CRS and the corresponding precision treatment, aiming to provide a reference for the formulation of clinical treatment strategies for CRS