Journal ID : CJOHNS-11-01-2023-11326
[This article belongs to Volume - 57, Issue - 08]

Title : Research progress on the mechanism of bitter taste receptors regulating nasal inflammatory diseases

Abstract :

Bitter taste receptors (taste receptor type II, TAS2R) are mainly distributed in taste receptor type II cells on taste buds and mediate the perception of bitter taste. Early people's understanding of the function of TAS2R was limited to the perception of bitter taste. In recent years, the distribution and expression and physiological functions of TAS2R in the respiratory tract, digestive system, and cardiovascular system have gradually attracted attention. Recent studies have found that TAS2R expressed in the nasal cavity can regulate nasal inflammatory factors, and is related to chronic sinusitis, allergic rhinitis and other diseases. This review summarizes the expression and distribution of TAS2R in the nasal cavity, and summarizes the physiological role of TAS2R in the nasal cavity into two aspects: "spear" and "shield", that is, to defend against pathogens by actively regulating natural immunity and increasing receptor expression Invasion and reduction of nasal inflammation are aimed at providing theoretical support for further research and providing a reference for finding new targets for the treatment of sinusitis and other diseases.

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