Acute respiratory infections (ARI) are common in adults. Honey is a natural and cost-effective option for the treatment of coughs associated with respiratory infections in adults. This study compares the efficacy of honey in the treatment of cough in adults with acute respiratory infections, in two honey Vs reference groups, in the Guelmim region of southern Morocco. This prospective study aimed to evaluate the therapeutic effect of honey on cough and sleep in the population consuming it versus a reference population, in basic health structures and the hospital in the town of Guelmim. The study period was between October 2022 and May 2023, and the method used was the questionnaire in addition to the exploitation of files and monitoring forms. We performed univariate and multivariate logistic regression analyses between the variables. Statistically significant differences between groups were tested using the Wilcoxon test. All analyses were performed using SAS software version 9.4. 834 patients participated in the study (honey group=417/reference group=417). On day 5, the mean global symptom score and cough severity were reduced in the honey group (19.9±4/1.36±0.79, p<0.001). Multivariate logistic regression showed that there was no significant difference between the two groups for the following variables: origin, type of ARI, smoking status, cough duration, frequency of daytime cough, cough type, and temperature. However, the two variables: associated diseases and frequency of nocturnal cough showed a significant reduction in symptoms in the honey group (OR= 16.32, [11.50-23.16], OR=0.45 [0.29- 0.7] 95% CI, p < 0.001). The present study examined the effect of honey on acute respiratory infections, focusing on cough and sleep. The results showed that honey had a beneficial effect on cough, significantly reducing its severity and frequency in adults with ARI.