According to WHO, an estimated 17.7 million deaths are attributable to cardiovascular disease, representing 31% of total global mortality. More than three quarters of cardiovascular disease-related deaths occur in low- and middle-income countries. This study aimed to determine the prevalence of hypercholesterolemia among the adult population in two regions of Morocco. Cross-sectional data were analyzed from 1495 Moroccan adults persons (18-110 years) who participated in the 2017 STEPS survey in the Rabat and Casablanca regions, blood lipids were measured: Hypercholesterolemia was defined as an elevated total cholesterol level ≥ 190 mg/dl and/or under medication. The prevalence of hypercholesterolemia in our study population was 13%. It was slightly higher in men (14.2%) than in women (12.6%). Compared with the reference groups, hypercholesterolemia was significantly higher in the overweight people (15.1%), in the obese population (15.3%), those with abdominal obesity (16.4%), and those with hyperglycemia (19%). In addition, the prevalence of hypertension was slightly higher in the population people who drink alcohol (17.5%), however the difference was not statistically significant. Most cardiovascular disease can be prevented by addressing behavioral risk factors: smoking, unhealthy diet and obesity, physical inactivity, and harmful alcohol use. People with cardiovascular disease or at high risk of cardiovascular disease (due to the presence of one or more risk factors require early detection and management, including psychological support and medication as needed.