Honey is one of the most important natural products in the world. It is at the forefront of these products because of its many benefits as a medicine, food and therapeutic product, and has been considered a major source of energy for centuries. The objective of this study to evaluate the knowledge and practices of honey use for acute respiratory infections in the Guelmim region of southern Morocco. This cross-sectional survey was conducted from January 2020 to July 2022. The participants were the inhabitants of the Guelmim region (n = 834). The language used in the questionnaire was French translated into Arabic for better understanding. The questionnaire was administered either online or in person. For the method, we used a bivariate analysis using the chi-square test and logistic regression. For the results, honey is used by the respondents for respiratory affections (82%). The purchase is done directly at the beekeeper and the cooperatives, and the consumers occasionally use honey (46.2%). According to the results obtained, 38% of the population prefer honey made from Saharan plants. Most of the people questioned (67.3%), consider honey as a complementary treatment. The survey also revealed that 57.7% of the population uses it for sore throat, followed by coughing with a percentage of 32.7%. In the present study, it can be seen that there is a statistically significant relationship between the use of honey and the level of knowledge (β = 2.96; ORa = 37.28; p = 0.00 ˂ 0.05). The survey highlighted a "poor" level of the population knowledge about the use and benefits of honey for acute respiratory infections (34.2%). We can conclude that factors such as honey use, age, education, presence of a chronic disease had a statistically significant influence on the level of knowledge about honey. In addition, the highest percentage of respondents used honey as a complementary treatment 67.3%.